Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

Cells induced into senescence exhibit a marked increase in the secretion of pro-inflammatory cytokines termed senescence-associated secretory phenotype (SASP). Here we report that SASP from senescent stromal fibroblasts promote spontaneous morphological changes accompanied by an aggressive migratory...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Aifuwa, Ivie, Giri, Anjil, Longe, Nick, Lee, Sang Hyuk, An, Steven S., Wirtz, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741548/
https://ncbi.nlm.nih.gov/pubmed/26483365
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