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ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens

Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 may be functionally redundant, as they share a highly conserved kinase domain. However, in this study, we report differential functi...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Priya, Rashmi, Liang, Xuan, Teo, Jessica L., Duszyc, Kinga, Yap, Alpha S., Gomez, Guillermo A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221615/
https://ncbi.nlm.nih.gov/pubmed/28035042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-04-0262
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