Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells

BACKGROUND: Multiple lines of evidence support that the Hedgehog (Hh) signalling has a role in the maintenance and progression of different human cancers. Therefore, inhibition of the Hh pathway represents a valid anticancer therapeutic approach for renal cell carcinoma (RCC) patients. NVP-LDE225 is...

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Bibliografiska uppgifter
I publikationen:Br J Cancer
Huvudupphovsmän: D'Amato, C, Rosa, R, Marciano, R, D'Amato, V, Formisano, L, Nappi, L, Raimondo, L, Di Mauro, C, Servetto, A, Fulciniti, F, Cipolletta, A, Bianco, C, Ciardiello, F, Veneziani, B M, De Placido, S, Bianco, R
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453852/
https://ncbi.nlm.nih.gov/pubmed/25093491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.421
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