NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128

Prostate cancer stem cells (CSCs) are defined by their extensive self-renewal, differentiation and tumor initiation properties. It is now clear that CSCs are involved in tumor growth and recurrence, and resistance to conventional treatments. The sonic hedgehog (Shh) pathway has a crucial role in ste...

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Bibliographische Detailangaben
Hauptverfasser: Nanta, R, Kumar, D, Meeker, D, Rodova, M, Van Veldhuizen, P J, Shankar, S, Srivastava, R K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641359/
https://ncbi.nlm.nih.gov/pubmed/23567619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.5
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