PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer

BACKGROUND: Tumour cells exclusively express the embryonic M2 isoform of pyruvate kinase (PKM2). PKM2 expression levels have been correlated with the effect of platinum compounds in cancer cell lines and xenograft models. The potential predictive role of PKM2 in patients with metastatic/advanced non...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Papadaki, C, Sfakianaki, M, Lagoudaki, E, Giagkas, G, Ioannidis, G, Trypaki, M, Tsakalaki, E, Voutsina, A, Koutsopoulos, A, Mavroudis, D, Georgoulias, V, Souglakos, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453739/
https://ncbi.nlm.nih.gov/pubmed/25233397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.492
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