Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC

In non-small-cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) and K-RAS mutations of the primary tumour are associated with responsiveness and resistance to tyrosine kinase inhibitors (TKIs), respectively. However, the EGFR and K-RAS mutation status in metastases is not well studied...

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Detalhes bibliográficos
Main Authors: Kalikaki, A, Koutsopoulos, A, Trypaki, M, Souglakos, J, Stathopoulos, E, Georgoulias, V, Mavroudis, D, Voutsina, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538768/
https://ncbi.nlm.nih.gov/pubmed/19238633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604629
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