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Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate

Codon pair bias (CPB), which has been observed in all organisms, is a neglected genomic phenomenon that affects gene expression. CPB results from synonymous codons that are paired more or less frequently in ORFeomes regardless of codon bias. The effect of an individual codon pair change is usually s...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Wang, Bingyin, Yang, Chen, Tekes, Gergely, Mueller, Steffen, Paul, Aniko, Whelan, Sean P. J., Wimmer, Eckard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453547/
https://ncbi.nlm.nih.gov/pubmed/25827413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00237-15
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