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Subducted and Melanotic Cells in Advanced Age-Related Macular Degeneration Are Derived From Retinal Pigment Epithelium

PURPOSE. To describe, illustrate, and account for two cell types plausibly derived from RPE in geographic atrophy (GA) and choroidal neovascularization (CNV) of AMD, using melanosomes, lipofuscin, and basal laminar deposit (BLamD) as anatomical markers. METHODS. Human donor eyes with GA (n = 13) or...

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Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Zanzottera, Emma C., Messinger, Jeffrey D., Ach, Thomas, Smith, R. Theodore, Curcio, Christine A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453434/
https://ncbi.nlm.nih.gov/pubmed/26024109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16432
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