Subducted and Melanotic Cells in Advanced Age-Related Macular Degeneration Are Derived From Retinal Pigment Epithelium

PURPOSE. To describe, illustrate, and account for two cell types plausibly derived from RPE in geographic atrophy (GA) and choroidal neovascularization (CNV) of AMD, using melanosomes, lipofuscin, and basal laminar deposit (BLamD) as anatomical markers. METHODS. Human donor eyes with GA (n = 13) or...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Zanzottera, Emma C., Messinger, Jeffrey D., Ach, Thomas, Smith, R. Theodore, Curcio, Christine A.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2015
Fag:
Retina
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453434/
https://ncbi.nlm.nih.gov/pubmed/26024109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16432
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