Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain

Chronic pain attenuates midbrain dopamine (DA) transmission, as evidenced by a decrease in opioid-evoked DA release in the ventral striatum, suggesting that the occurrence of chronic pain impairs reward-related behaviors. However, mechanisms by which pain modifies DA transmission remain elusive. Usi...

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Pubblicato in:J Neurosci
Autori principali: Taylor, Anna M. W., Castonguay, Annie, Taylor, Alison J., Murphy, Niall P., Ghogha, Atefeh, Cook, Christopher, Xue, Lihua, Olmstead, Mary C., De Koninck, Yves, Evans, Christopher J., Cahill, Catherine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452552/
https://ncbi.nlm.nih.gov/pubmed/26041913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4036-14.2015
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