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Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry
Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Im...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528534/ https://ncbi.nlm.nih.gov/pubmed/23184995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214605109 |
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