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Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Im...

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Main Authors: Navratilova, Edita, Xie, Jennifer Y., Okun, Alec, Qu, Chaoling, Eyde, Nathan, Ci, Shuang, Ossipov, Michael H., King, Tamara, Fields, Howard L., Porreca, Frank
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528534/
https://ncbi.nlm.nih.gov/pubmed/23184995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214605109
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