Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies

BACKGROUND: Glycoprotein VI (GPVI) is the essential platelet collagen receptor in atherothrombosis, but its inhibition causes only a mild bleeding tendency. Thus, targeting this receptor has selective antithrombotic potential. OBJECTIVES: This study sought to compare compounds interfering with plate...

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Detalhes bibliográficos
Publicado no:J Am Coll Cardiol
Main Authors: Jamasbi, Janina, Megens, Remco T.A., Bianchini, Mariaelvy, Münch, Götz, Ungerer, Martin, Faussner, Alexander, Sherman, Shachar, Walker, Adam, Goyal, Pankaj, Jung, Stephanie, Brandl, Richard, Weber, Christian, Lorenz, Reinhard, Farndale, Richard, Elia, Natalie, Siess, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Biomedical 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452546/
https://ncbi.nlm.nih.gov/pubmed/26046734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2015.03.573
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