Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc. Cross-linking potentiated the inhibition of human plaque- and collagen-induced platelet aggreg...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Jamasbi, Janina, Megens, Remco T.A., Bianchini, Mariaelvy, Uhland, Kerstin, Münch, Götz, Ungerer, Martin, Sherman, Shachar, Faussner, Alexander, Brandl, Richard, John, Christine, Buchner, Johannes, Weber, Christian, Lorenz, Reinhard, Elia, Natalie, Siess, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRE-CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063538/
https://ncbi.nlm.nih.gov/pubmed/27766315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.03.008
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