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A Structural Perspective on the Regulation of the EGF Receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a critical role in the pathogenesis of many cancers. EGFR is unique in that its ligand-induced dimerization is established solely by contacts between regions of the receptor that are occluded within the monomeric, u...
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| Publicado no: | Annu Rev Biochem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452390/ https://ncbi.nlm.nih.gov/pubmed/25621509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-060614-034402 |
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