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Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)

More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zorn, Julie A., Wang, Qi, Fujimura, Eric, Barros, Tiago, Kuriyan, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383440/
https://ncbi.nlm.nih.gov/pubmed/25837374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121177
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