Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis

Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase. In mice, mSirt1 deficiency causes the onset of fatty liver via regulation of the hepatic nutrient metabolism pathway. In this study, we demonstrate SIRT1 expression, activity and NAD...

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Bibliografski detalji
Izdano u:Cancer Sci
Glavni autori: Konishi, Hideyuki, Shirabe, Ken, Nakagawara, Hidekazu, Harimoto, Norifumi, Yamashita, Yo-Ichi, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Oda, Yoshinao, Maehara, Yoshihiko
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2015
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452154/
https://ncbi.nlm.nih.gov/pubmed/25736100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12653
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