Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis

Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase. In mice, mSirt1 deficiency causes the onset of fatty liver via regulation of the hepatic nutrient metabolism pathway. In this study, we demonstrate SIRT1 expression, activity and NAD...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Konishi, Hideyuki, Shirabe, Ken, Nakagawara, Hidekazu, Harimoto, Norifumi, Yamashita, Yo-Ichi, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Oda, Yoshinao, Maehara, Yoshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452154/
https://ncbi.nlm.nih.gov/pubmed/25736100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12653
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