Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis

Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase. In mice, mSirt1 deficiency causes the onset of fatty liver via regulation of the hepatic nutrient metabolism pathway. In this study, we demonstrate SIRT1 expression, activity and NAD...

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Publicat a:Cancer Sci
Autors principals: Konishi, Hideyuki, Shirabe, Ken, Nakagawara, Hidekazu, Harimoto, Norifumi, Yamashita, Yo-Ichi, Ikegami, Toru, Yoshizumi, Tomoharu, Soejima, Yuji, Oda, Yoshinao, Maehara, Yoshihiko
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452154/
https://ncbi.nlm.nih.gov/pubmed/25736100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12653
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