A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy

Members of the PI3K/Akt/mTor signaling cascade are among the most frequently altered proteins in cancer, yet the therapeutic application of pharmacological inhibitors of this signaling network, either as monotherapy or in combination therapy (CT) has so far not been particularly successful. In this...

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Bibliographic Details
Published in:Mol Cell Ther
Main Authors: Westhoff, Mike-Andrew, Karpel-Massler, Georg, Brühl, Oliver, Enzenmüller, Stefanie, La Ferla-Brühl, Katia, Siegelin, Markus D, Nonnenmacher, Lisa, Debatin, Klaus-Michael
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452069/
https://ncbi.nlm.nih.gov/pubmed/26056598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2052-8426-2-32
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