A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy

Members of the PI3K/Akt/mTor signaling cascade are among the most frequently altered proteins in cancer, yet the therapeutic application of pharmacological inhibitors of this signaling network, either as monotherapy or in combination therapy (CT) has so far not been particularly successful. In this...

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Detalhes bibliográficos
Publicado no:Mol Cell Ther
Main Authors: Westhoff, Mike-Andrew, Karpel-Massler, Georg, Brühl, Oliver, Enzenmüller, Stefanie, La Ferla-Brühl, Katia, Siegelin, Markus D, Nonnenmacher, Lisa, Debatin, Klaus-Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452069/
https://ncbi.nlm.nih.gov/pubmed/26056598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2052-8426-2-32
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