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A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the PI3K/Akt/mTOR have been found, making this survival cascade a promising therapeutic target, particular for combination therapy t...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Ströbele, Stephanie, Schneider, Matthias, Schneele, Lukas, Siegelin, Markus D., Nonnenmacher, Lisa, Zhou, Shaoxia, Karpel-Massle, Georg, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Debatin, Klaus-Michael
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488267/
https://ncbi.nlm.nih.gov/pubmed/26121251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131670
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