A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the PI3K/Akt/mTOR have been found, making this survival cascade a promising therapeutic target, particular for combination therapy t...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ströbele, Stephanie, Schneider, Matthias, Schneele, Lukas, Siegelin, Markus D., Nonnenmacher, Lisa, Zhou, Shaoxia, Karpel-Massle, Georg, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Debatin, Klaus-Michael
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488267/
https://ncbi.nlm.nih.gov/pubmed/26121251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131670
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