A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the PI3K/Akt/mTOR have been found, making this survival cascade a promising therapeutic target, particular for combination therapy t...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Ströbele, Stephanie, Schneider, Matthias, Schneele, Lukas, Siegelin, Markus D., Nonnenmacher, Lisa, Zhou, Shaoxia, Karpel-Massle, Georg, Westhoff, Mike-Andrew, Halatsch, Marc-Eric, Debatin, Klaus-Michael
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4488267/
https://ncbi.nlm.nih.gov/pubmed/26121251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131670
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