Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes

Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role in the pathogenesis of diabetic nephropathy (DN). The efficacy of the Nox1/Nox4 inhibitor GKT137831 on the manifestations of DN was studied in OVE26 mice, a model of type 1 diabetes. Starting at 4–5 mo of age, OVE...

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Vydáno v:Am J Physiol Renal Physiol
Hlavní autoři: Gorin, Yves, Cavaglieri, Rita C., Khazim, Khaled, Lee, Doug-Yoon, Bruno, Francesca, Thakur, Sachin, Fanti, Paolo, Szyndralewiez, Cédric, Barnes, Jeffrey L., Block, Karen, Abboud, Hanna E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451325/
https://ncbi.nlm.nih.gov/pubmed/25656366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00396.2014
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