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The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo
Podocyte injury, a major contributor to the pathogenesis of diabetic nephropathy, is caused at least in part by the excessive generation of reactive oxygen species (ROS). Overproduction of superoxide by the NADPH oxidase isoform Nox4 plays an important role in podocyte injury. The plant extract sily...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3761209/ https://ncbi.nlm.nih.gov/pubmed/23804455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00028.2013 |
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