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The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo

Podocyte injury, a major contributor to the pathogenesis of diabetic nephropathy, is caused at least in part by the excessive generation of reactive oxygen species (ROS). Overproduction of superoxide by the NADPH oxidase isoform Nox4 plays an important role in podocyte injury. The plant extract sily...

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Bibliografske podrobnosti
Main Authors: Khazim, Khaled, Gorin, Yves, Cavaglieri, Rita Cassia, Abboud, Hanna E., Fanti, Paolo
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761209/
https://ncbi.nlm.nih.gov/pubmed/23804455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00028.2013
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