C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

[Image: see text] Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the kappa opioid and nociceptin/orphanin FQ peptide receptors. Th...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Cueva, Juan Pablo, Roche, Christopher, Ostovar, Mehrnoosh, Kumar, Vinod, Clark, Mary J., Hillhouse, Todd M., Lewis, John W., Traynor, John R., Husbands, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450370/
https://ncbi.nlm.nih.gov/pubmed/25898137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00130
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