Heparanase Stimulates Chondrogenesis and Is Up-Regulated in Human Ectopic Cartilage: A Mechanism Possibly Involved in Hereditary Multiple Exostoses

Hereditary multiple exostoses is a pediatric skeletal disorder characterized by benign cartilaginous tumors called exostoses that form next to growing skeletal elements. Hereditary multiple exostoses patients carry heterozygous mutations in the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2,...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Huegel, Julianne, Enomoto-Iwamoto, Motomi, Sgariglia, Federica, Koyama, Eiki, Pacifici, Maurizio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2015
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450318/
https://ncbi.nlm.nih.gov/pubmed/25863260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.02.014
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