Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction and ectopic cartilage formation in mouse cranial base synchondroses

The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill defined. Here we created mice deficient in Kif3a in cartilage and focused on the cranial base and synchondroses. Kif3a deficiency caused cranial base growth retardation...

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Bibliografiske detaljer
Main Authors: Koyama, Eiki, Young, Blanche, Shibukawa, Yoshihiro, Nagayama, Motohiro, Enomoto-Iwamoto, Motomi, Iwamoto, Masahiro, Maeda, Yukiko, Lanske, Beate, Song, Buer, Serra, Rosa, Pacifici, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776720/
https://ncbi.nlm.nih.gov/pubmed/17507416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.001586
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