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Differential Role of Insulin/IGF-1 Receptor Signaling on Muscle Growth and Glucose Homeostasis
Insulin and IGF-1 are major regulators of muscle protein and glucose homeostasis. To determine how these pathways interact, we generated mice with muscle-specific knockout of IGF-1 receptor (IGF1R) and insulin receptor (IR). These MIGIRKO mice showed >60% decrease in muscle mass. Despite a comple...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4449334/ https://ncbi.nlm.nih.gov/pubmed/25981038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.037 |
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