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Differential Role of Insulin/IGF-1 Receptor Signaling on Muscle Growth and Glucose Homeostasis

Insulin and IGF-1 are major regulators of muscle protein and glucose homeostasis. To determine how these pathways interact, we generated mice with muscle-specific knockout of IGF-1 receptor (IGF1R) and insulin receptor (IR). These MIGIRKO mice showed >60% decrease in muscle mass. Despite a comple...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: O'Neill, Brian T., Lauritzen, Hans P. M. M., Hirshman, Michael F., Smyth, Graham, Goodyear, Laurie J., Kahn, C. Ronald
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449334/
https://ncbi.nlm.nih.gov/pubmed/25981038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.037
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