Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits immunized with virus-like particles (VLPs) express...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Crooks, Ema T., Tong, Tommy, Chakrabarti, Bimal, Narayan, Kristin, Georgiev, Ivelin S., Menis, Sergey, Huang, Xiaoxing, Kulp, Daniel, Osawa, Keiko, Muranaka, Janelle, Stewart-Jones, Guillaume, Destefano, Joanne, O’Dell, Sijy, LaBranche, Celia, Robinson, James E., Montefiori, David C., McKee, Krisha, Du, Sean X., Doria-Rose, Nicole, Kwong, Peter D., Mascola, John R., Zhu, Ping, Schief, William R., Wyatt, Richard T., Whalen, Robert G., Binley, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449185/
https://ncbi.nlm.nih.gov/pubmed/26023780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004932
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