Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6

Because a temporal arrest in the G(1) phase of the cell cycle is thought to be a prerequisite for cell differentiation, we investigated cell cycle factors that critically influence the differentiation of mouse osteoblastic MC3T3-E1 cells induced by bone morphogenetic protein 2 (BMP-2), a potent indu...

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Detalhes bibliográficos
Main Authors: Ogasawara, Toru, Kawaguchi, Hiroshi, Jinno, Shigeki, Hoshi, Kazuto, Itaka, Keiji, Takato, Tsuyoshi, Nakamura, Kozo, Okayama, Hiroto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC444857/
https://ncbi.nlm.nih.gov/pubmed/15254224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6560-6568.2004
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