Dual Roles of Smad Proteins in the Conversion from Myoblasts to Osteoblastic Cells by Bone Morphogenetic Proteins

Bone morphogenetic proteins (BMPs) induce ectopic bone formation in muscle tissue in vivo and convert myoblasts such that they differentiate into osteoblastic cells in vitro. We report here that constitutively active Smad1 induced osteoblastic differentiation of C2C12 myoblasts in cooperation with S...

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Main Authors: Nojima, Junya, Kanomata, Kazuhiro, Takada, Yumi, Fukuda, Toru, Kokabu, Shoichiro, Ohte, Satoshi, Takada, Takatora, Tsukui, Tohru, Yamamoto, Takamasa S., Sasanuma, Hiroki, Yoneyama, Katsumi, Ueno, Naoto, Okazaki, Yasushi, Kamijo, Ryutaro, Yoda, Tetsuya, Katagiri, Takenobu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865305/
https://ncbi.nlm.nih.gov/pubmed/20231279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028019
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