Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethalit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC444850/
https://ncbi.nlm.nih.gov/pubmed/15254230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6631-6634.2004
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados