Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethalit...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2004
Gaiak:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC444850/
https://ncbi.nlm.nih.gov/pubmed/15254230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6631-6634.2004
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