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Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethalit...

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Udgivet i:Mol Cell Biol
Principais autores: Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444850/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254230/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.15.6631-6634.2004
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