mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

TOR is a serine-threonine kinase that was originally identified as a target of rapamycin in Saccharomyces cerevisiae and then found to be highly conserved among eukaryotes. In Drosophila melanogaster, inactivation of TOR or its substrate, S6 kinase, results in reduced cell size and embryonic lethali...

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Détails bibliographiques
Auteurs principaux: Murakami, Mirei, Ichisaka, Tomoko, Maeda, Mitsuyo, Oshiro, Noriko, Hara, Kenta, Edenhofer, Frank, Kiyama, Hiroshi, Yonezawa, Kazuyoshi, Yamanaka, Shinya
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC444840/
https://ncbi.nlm.nih.gov/pubmed/15254238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.15.6710-6718.2004
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