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Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme

Elastase-like enzymes are involved in important diseases such as acute pancreatitis, chronic inflammatory lung diseases, and cancer. Structural insights into their interaction with specific inhibitors will contribute to the development of novel anti-elastase compounds that resist rapid oxidation and...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: García-Fernández, Rossana, Perbandt, Markus, Rehders, Dirk, Ziegelmüller, Patrick, Piganeau, Nicolas, Hahn, Ulrich, Betzel, Christian, Chávez, María de los Ángeles, Redecke, Lars
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447985/
https://ncbi.nlm.nih.gov/pubmed/25878249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.647586
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