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Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L
The Kunitz-type protease inhibitor ShPI-1 inhibits human neutrophil elastase (HNE, K (i) = 2.35·10(−8) M) but does not interact with the porcine pancreatic elastase (PPE); whereas its P1 site variant, ShPI-1/K13L, inhibits both HNE and PPE (K (i) = 1.3·10(−9) M, and K (i) = 1.2·10(−8) M, respectivel...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570792/ https://ncbi.nlm.nih.gov/pubmed/26372354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137787 |
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