Polar Desolvation and Position 226 of Pancreatic and Neutrophil Elastases Are Crucial to their Affinity for the Kunitz-Type Inhibitors ShPI-1 and ShPI-1/K13L

The Kunitz-type protease inhibitor ShPI-1 inhibits human neutrophil elastase (HNE, K (i) = 2.35·10(−8) M) but does not interact with the porcine pancreatic elastase (PPE); whereas its P1 site variant, ShPI-1/K13L, inhibits both HNE and PPE (K (i) = 1.3·10(−9) M, and K (i) = 1.2·10(−8) M, respectivel...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Hernández González, Jorge Enrique, García-Fernández, Rossana, Valiente, Pedro Alberto
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570792/
https://ncbi.nlm.nih.gov/pubmed/26372354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137787
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