Polymorphisms in Regulator of Protease B (RopB) Alter Disease Phenotype and Strain Virulence of Serotype M3 Group A Streptococcus

Whole-genome sequencing of serotype M3 group A streptococci (GAS) from oropharyngeal and invasive infections in Ontario recently showed that the gene encoding regulator of protease B (RopB) is highly polymorphic in this population. To test the hypothesis that ropB is under diversifying selective pre...

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Bibliografiska uppgifter
I publikationen:J Infect Dis
Huvudupphovsmän: Olsen, Randall J., Laucirica, Daniel R., Watkins, M. Ebru, Feske, Marsha L., Garcia-Bustillos, Jesus R., Vu, Chau, Cantu, Concepcion, Shelburne, Samuel A., Fittipaldi, Nahuel, Kumaraswami, Muthiah, Shea, Patrick R., Flores, Anthony R., Beres, Stephen B., Lovgren, Maguerite, Tyrrell, Gregory J., Efstratiou, Androulla, Low, Donald E., Van Beneden, Chris A., Musser, James M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2012
Ämnen:
Major Articles and Brief Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447876/
https://ncbi.nlm.nih.gov/pubmed/22262791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir825
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