Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

BACKGROUND: The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease. We assessed the efficacy of obeticholic acid in adult patients with non-alcoholi...

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Foilsithe in:Lancet
Main Authors: Neuschwander-Tetri, Brent A, Loomba, Rohit, Sanyal, Arun J, Lavine, Joel E, Van Natta, Mark L, Abdelmalek, Manal F, Chalasani, Naga, Dasarathy, Srinivasan, Diehl, Anna Mae, Hameed, Bilal, Kowdley, Kris V, McCullough, Arthur, Terrault, Norah, Clark, Jeanne M, Tonascia, James, Brunt, Elizabeth M, Kleiner, David E, Doo, Edward
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447192/
https://ncbi.nlm.nih.gov/pubmed/25468160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(14)61933-4
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