Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

BACKGROUND: The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X nuclear receptor that reduces liver fat and fibrosis in animal models of fatty liver disease. We assessed the efficacy of obeticholic acid in adult patients with non-alcoholi...

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Dades bibliogràfiques
Publicat a:Lancet
Autors principals: Neuschwander-Tetri, Brent A, Loomba, Rohit, Sanyal, Arun J, Lavine, Joel E, Van Natta, Mark L, Abdelmalek, Manal F, Chalasani, Naga, Dasarathy, Srinivasan, Diehl, Anna Mae, Hameed, Bilal, Kowdley, Kris V, McCullough, Arthur, Terrault, Norah, Clark, Jeanne M, Tonascia, James, Brunt, Elizabeth M, Kleiner, David E, Doo, Edward
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447192/
https://ncbi.nlm.nih.gov/pubmed/25468160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(14)61933-4
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