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High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
Nucleoli are not only organelles that produce ribosomal subunits. They are also overarching sensors of different stress conditions and they control specific nucleolar stress pathways leading to stabilization of p53. During DNA replication, ATR and its activator TopBP1 initiate DNA damage response up...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4446431/ https://ncbi.nlm.nih.gov/pubmed/25916852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv371 |
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