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Inhibition of Dihydropteroate Synthetase from Escherichia coli by Sulfones and Sulfonamides

The inhibitory action of various diphenylsulfones and sulfonamides on dihydropteroate synthetase partially purified from Escherichia coli was examined. 4,4′-Diaminodiphenylsulfone (DDS; I(50) = 2 × 10(−5) M) and the monosubstituted derivatives 4-amino-4′-formamidodiphenylsulfone (I(50) = 5.8 × 10(−5...

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Détails bibliographiques
Auteurs principaux: McCullough, Jerry L., Maren, Thomas H.
Format: Artigo
Langue:Inglês
Publié: 1973
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC444477/
https://ncbi.nlm.nih.gov/pubmed/4597736
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