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Inhibition of Dihydropteroate Synthetase from Escherichia coli by Sulfones and Sulfonamides

The inhibitory action of various diphenylsulfones and sulfonamides on dihydropteroate synthetase partially purified from Escherichia coli was examined. 4,4′-Diaminodiphenylsulfone (DDS; I(50) = 2 × 10(−5) M) and the monosubstituted derivatives 4-amino-4′-formamidodiphenylsulfone (I(50) = 5.8 × 10(−5...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: McCullough, Jerry L., Maren, Thomas H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 1973
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC444477/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4597736/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.3.6.665
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