Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia

BACKGROUND: DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at R882 in the methyltransferase domain o...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Berenstein, Rimma, Blau, Igor Wolfgang, Suckert, Nikola, Baldus, Claudia, Pezzutto, Antonio, Dörken, Bernd, Blau, Olga
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443651/
https://ncbi.nlm.nih.gov/pubmed/25994761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0173-2
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