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IGFBP-3 reduces eNOS and PKCzeta phosphorylation, leading to lowered VEGF levels

PURPOSE: In models of diabetic retinopathy, insulin-like growth factor binding protein-3 (IGFBP-3) is protective to the retina, especially retinal microvascular endothelial cells (RECs), but the underlying mechanisms are unclear. For this study, we hypothesized that IGFBP-3 may reduce vascular endot...

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Detalhes bibliográficos
Publicado no:Mol Vis
Main Authors: Zhang, Qiuhua, Jiang, Youde, Steinle, Jena J.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443585/
https://ncbi.nlm.nih.gov/pubmed/26015772
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