Hydration water mobility is enhanced around tau amyloid fibers

The paired helical filaments (PHF) formed by the intrinsically disordered human protein tau are one of the pathological hallmarks of Alzheimer disease. PHF are fibers of amyloid nature that are composed of a rigid core and an unstructured fuzzy coat. The mechanisms of fiber formation, in particular...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Fichou, Yann, Schirò, Giorgio, Gallat, François-Xavier, Laguri, Cedric, Moulin, Martine, Combet, Jérôme, Zamponi, Michaela, Härtlein, Michael, Picart, Catherine, Mossou, Estelle, Lortat-Jacob, Hugues, Colletier, Jacques-Philippe, Tobias, Douglas J., Weik, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443308/
https://ncbi.nlm.nih.gov/pubmed/25918405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422824112
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