Hydration water mobility is enhanced around tau amyloid fibers

The paired helical filaments (PHF) formed by the intrinsically disordered human protein tau are one of the pathological hallmarks of Alzheimer disease. PHF are fibers of amyloid nature that are composed of a rigid core and an unstructured fuzzy coat. The mechanisms of fiber formation, in particular...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fichou, Yann, Schirò, Giorgio, Gallat, François-Xavier, Laguri, Cedric, Moulin, Martine, Combet, Jérôme, Zamponi, Michaela, Härtlein, Michael, Picart, Catherine, Mossou, Estelle, Lortat-Jacob, Hugues, Colletier, Jacques-Philippe, Tobias, Douglas J., Weik, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443308/
https://ncbi.nlm.nih.gov/pubmed/25918405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422824112
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