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Yes-associated protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy

Mechanically-induced skeletal muscle growth is regulated by mTORC1. YAP is a mechanically-sensitive, and growth-related, transcriptional co-activator that can regulate mTORC1. Here we show that, in skeletal muscle, mechanical overload promotes an increase in YAP expression; however, the time course...

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Publicat a:FEBS Lett
Autors principals: Goodman, Craig A., Dietz, Jason M., Jacobs, Brittany L., McNally, Rachel M., You, Jae-Sung, Hornberger, Troy A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442043/
https://ncbi.nlm.nih.gov/pubmed/25959868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.04.047
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