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Differential Fc-receptor engagement drives an anti-tumor vaccinal effect

Passively-administered anti-tumor mAbs rapidly kill tumor targets via FcγR-mediated cytotoxicity (ADCC), a short-term process. However, anti-tumor mAb treatment can also induce a vaccinal effect, in which mAb-mediated tumor death induces a long-term anti-tumor cellular immune response. To determine...

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Podrobná bibliografie
Vydáno v:Cell
Hlavní autoři: DiLillo, David J., Ravetch, Jeffrey V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441863/
https://ncbi.nlm.nih.gov/pubmed/25976835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.016
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