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Differential Fc-receptor engagement drives an anti-tumor vaccinal effect
Passively-administered anti-tumor mAbs rapidly kill tumor targets via FcγR-mediated cytotoxicity (ADCC), a short-term process. However, anti-tumor mAb treatment can also induce a vaccinal effect, in which mAb-mediated tumor death induces a long-term anti-tumor cellular immune response. To determine...
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| Publicado no: | Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4441863/ https://ncbi.nlm.nih.gov/pubmed/25976835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.04.016 |
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